异戊烯半胱氨酸羧基甲基转移酶抗体
规格：1mg/1ml
英文名： ICMT
别名： HSTE14; Icmt; ICMT_HUMAN; Isoprenylcysteine carboxylmethyltransferase; MGC39955; MGC95322; MST098; MSTP098; pcCMT; PCMT; PPMT; Prenylated protein carboxyl methyltransferase; Prenylcysteine carboxyl me
分子量： 32kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CMT/Icmt
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆 细胞膜
异戊烯半胱氨酸羧基甲基转移酶抗体产品介绍：background: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Tissue specificity: Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. Function: Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Ubiquitously 异戊烯半胱氨酸羧基甲基转移酶抗体expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons. Similarity: Belongs to the isoprenylcysteine O-methyltransferase family. Database links: UniProtKB/Swiss-Prot: O60725.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or异戊烯半胱氨酸羧基甲基转移酶抗体 diagnostic applications. Icmt酶是异戊烯途径中的一种关键酶，它能将甲基加到Ras上。这种甲基标签能使Ras到达细胞中的*终目的地，Icmt酶能发送不控制生长的信号，因此，Icmt蛋白在保持细胞中的致癌基因Ras的开启状态中起到重要作用。（Ras是细胞的一种正常的遗传成分，但是这种基因的突变能够致使它促进细胞的失控生长。而且，在一异戊烯半胱氨酸羧基甲基转移酶抗体半的结肠癌和90％的胰腺癌中发生了Ras基因突变）。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid