砷酸盐转运三磷酸腺苷酶抗体

砷酸盐转运三磷酸腺苷酶抗体

规格：1mg/1ml

英文名： ASNA1

别名： ARSA 1; ARSA; ArsA arsenite transporter ATP binding homolog 1; ArsA arsenite transporter, ATP binding, E. coli, homolog of, 1; ArsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ARSA I; AR

分子量： 39kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human ASNA1

交叉反应：Human, Mouse, Rat, Chicken, Horse, Sheep,

细胞定位：细胞核 细胞浆

砷酸盐转运三磷酸腺苷酶抗体产品介绍：background: ASNA1 is the human homolog of the E.coli arsA gene which is an ATPase, and is the catalytic component of a multisubunit oxyanion pump responsible for resistance to arsenicals and antimonials. Function: This gene represents the human homolog of the bacterialarsA gene, encoding the arsenite-stimulated ATPase component of thearsenite transporter responsible for resistance to arsenicals. Thisprotein is also a central component of a transmembrane domain (TMD)recognition complex (TRC) that is involved in thepost-translational delivery of tail-anchored (TA) proteins from thecytosol to the endoplasmic reticulum (ER). It recognizes andselectively binds the TMD of TA proteins in the cytosol, anddelivers them to the ER for insertion. [provided by RefSeq, Oct2011]. [FUNCTION] ATPase required for the post-translational delivery oftail-anchored (TA) proteins to the endoplasmic reticulum.Recognizes and selectively binds the transmembrane domain of TAproteins in the cytosol. This complex then targets to theendoplasmic reticulum by membrane-bound receptors, where thetail-anchored 砷酸盐转运三磷酸腺苷酶抗体protein is released for insertion. This process isregulated by ATP binding and hydrolysis. ATP binding drives thehomodimer towards the closed dimer state, facilitating recognitionof newly synthesized TA membrane proteins. ATP hydrolysis isrequired for insertion. Subsequently, the homodimer reverts towardsthe open dimer state, lowering its affinity for the membrane-boundreceptor, and returning it to the cytosol to initiate a new roundof targeting (By similarity). May be involved in insulin signaling. Subunit: Homodimer (By similarity). Component of a transmembranedomain recognition complex (TRC) (By similarity). Interacts withSERP1 and SEC61B (By similarity). Interacts with WRB. Subcellular Location: Cytoplasm. Endoplasmic reticulum. Nucleus,nucleolus. Tissue Specificity: Expressed in the epithelial cells of theliver, kidney, and stomach wall, in砷酸盐转运三磷酸腺苷酶抗体 the adrenal medulla, in theislet cells of the pancreas, in the red pulp of the spleen, and incardiac and skeletal muscle. Similarity: Belongs to the arsA ATPase family. Gene ID: 439 Database links: Entrez Gene: 439 Human Entrez Gene: 56495 Mouse Entrez Gene: 288919 Rat GenBank: NP_004308.2 Human Omim: 601913 Human SwissProt: O43681 Human SwissProt: O54984 Mouse Unigene: 465985 Human Unigene: 41475 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

砷酸盐转运三磷酸腺苷酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：细胞生物  信号转导  转录调节因子  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

产品留言

标题

联系人

联系电话

内容

验证码

点击换一张

注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!