S期激酶活化蛋白DBF4A抗体
规格：1mg/1ml
英文名： DBF4A
别名： Activator of S phase kinase; ASK; Chiffon homolog A; DBF4; DBF4 type zinc finger containing protein 1; DBF4-type zinc finger-containing protein 1; DBF4A; DBF4A_HUMAN; Protein DBF4 homolog A; ZDBF1.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human DBF4A
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
S期激酶活化蛋白DBF4A抗体产品介绍：background: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines. Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. S期激酶活化蛋白DBF4A抗体Subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6. Subcellular Location: Nucleus. Tissue Specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Contains 2 BRCT domains. Contains 1 DBF4-type zinc finger. Database links: UniProtKB/Swiss-Prot: Q9UBU7S期激酶活化蛋白DBF4A抗体.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
S期激酶活化蛋白DBF4A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid