细胞周期G1的相互作用蛋白抗体
规格：1mg/1ml
英文名： MNAT1
别名： MNAT 1; CAP35; CDK activating kinase assembly factor MAT1; CDK7/cyclin H assembly factor; Cyclin G1 interacting protein; MAT1; Menage a trois; MNAT 1; p35; p36; RING finger protein 66; RING finger pro
分子量： 36kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MNAT1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞核
细胞周期G1的相互作用蛋白抗体产品介绍：background: MNAT1 (or 'menage a trois-1') is a subunit of the CAK complex which is a multisubunit protein that includes CDK7, cyclin H, as well as MNAT1. CAK (CDK-activating kinase) phosphorylates and thus activates CDKS (Cyclin-dependent kinases) which play an essential role in cell cycle control of eukaryotic cells. Function: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Subunit: Associates primarily with CDK7 and cyclin H to form the CAK complex. 细胞周期G1的相互作用蛋白抗体CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor. Subcellular Location: Nucleus. Tissue Specificity: Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes. Similarity: Contains 1 RING-type zinc finger. Contains 1 UIM (ubiquitin-interacting motif) repeat. Database links: Entrez Gene: 4331 Human Entrez Gene: 17420 Mouse Entrez Gene: 266713 Rat Omim: 602659 Human SwissProt: P51948 Human SwissProt: 细胞周期G1的相互作用蛋白抗体P51949 Mouse Unigene: 509523 Human Unigene: 246750 Mouse Unigene: 15168 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
细胞周期G1的相互作用蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 激酶和磷酸酶 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid