蛋白激酶Cα相互作用蛋白1抗体
规格：1mg/1ml
英文名： PICK1
别名： PICK 1; Pick1; PICK1_HUMAN; PRKCA binding protein; PRKCA-binding protein; Prkcabp; Protein interacting with C kinase 1; Protein interacting with PRKCA; Protein interacting with PRKCA 1; Protein kinase
分子量： 46kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human PICK1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse,
细胞定位：细胞浆 细胞膜
蛋白激酶Cα相互作用蛋白1抗体产品介绍：background: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel. Function: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ACCN3/ACCN2 channel. Subunit: Monomer and homodimer. Subcellular Location: Cytoplasm, perinuclear region. Cell junction, synapse. Note=Also present at excitatory synapses. Tissue Specificity:蛋白激酶Cα相互作用蛋白1抗体 Ubiquitous. Post-translational modifications: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Similarity: Contains 1 AH domain. Contains 1 PDZ (DHR) domain. Database links: UniProtKB/Swiss-Prot: Q9NRD5.2 Entrez Gene: 9463 Human Entrez Gene: 18693 Mouse Entrez Gene: 84591 Rat Omim: 605926 Human SwissProt: Q9NRD5 Human SwissProt: Q62083 Mouse SwissProt: 蛋白激酶Cα相互作用蛋白1抗体Q9EP80 Rat Unigene: 180871 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PICK1是衔接PKCα和膜上众多受体的关键蛋白之一，是细胞质中的膜结合蛋白,在蛋白质转运,以及细胞内信号转导过程中发挥重要作用；而在男性不育方面，PICK1蛋白也是促进精子顶体发育的关键蛋白，缺失PICK1蛋白将导致精子受破坏，失去活动能力和受精能力。
蛋白激酶Cα相互作用蛋白1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 激酶和磷酸酶
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid