Zona pellucida glycoprotein 2抗体

Zona pellucida glycoprotein 2抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-8120R

英文名称Zona pellucida glycoprotein 2

中文名称卵母细胞透明带糖蛋白2抗体

别    名OTTHUMP; Processed zona pellucida sperm-binding protein 2; Zona pellucida glycoprotein 2; zona pellucida glycoprotein ZP2; Zona pellucida protein A; Zp-2; ZP2; ZP2_HUMAN; ZPA.  

说 明 书100ul  200ul

研究领域细胞生物  发育生物学  

抗体来源Rabbit

克隆类型Polyclonal

Zona pellucida glycoprotein 2抗体交叉反应 Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, Bos taurus

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量78kDa

细胞定位细胞膜 分泌型蛋白

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human Zona pellucida glycoprotein 2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍Function:

The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.

Subcellular Location:

Secreted > extracellular space > extracellular matrix and Cell membrane.

Tissue Specificity:

Oocytes.

Post-translational modifications:

Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.

Additional proteolytically cleavage of the N-terminal peptide of 30 kDa occurs in one-cell and two-cell embryos (By similarity). Proteolytically cleaved in the N-terminal part probably by the metalloendopeptidase ASTL exocytosed from cortical granules after fertilization, yielding a N-terminal peptide of about 30 kDa which remains covalently attached to the C-terminal peptide via disulfide bond(s). This cleavage may play an important role in the post-fertilization block to polyspermy.

-glycosylated; N-linked glycans are of high-mannose/hybrid type, as well as bi-, tri- and tetra-antennary sialylated complex types.

O-glycosylated; contains sulfate-substituted glycans.

Similarity:

Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers.

SWISS:

Q05996

Gene ID:

7783