Zfp91抗体

Zfp91抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-1941R

英文名称Zfp91

中文名称白血病相关新基因抗体

别    名zinc finger protein 91; FKSG11; HGNC:14983; PZF; zinc finger protein 91 homolog (mouse); zinc finger protein homologous to mouse Zfp91; ZFP91_HUMAN.  

说 明 书100ul  200ul

研究领域肿瘤  细胞生物  **学  染色质和核信号  神经生物学  细胞凋亡  转录调节因子  结合蛋白  细胞分化  

抗体来源Rabbit

克隆类型Polyclonal

Zfp91抗体交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量63kDa

细胞定位细胞核

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human Zfp91

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The protein encoded by ZFP91 is a member of the zinc finger family of proteins. This protein contains C2H2 type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis Found in all the examined tissues including brain, heart, kidney, lung, liver, spleen, thymus, skeletal muscle, ovary and testis. Belongs to the krueppel C2H2-type zinc-finger protein family.

Function:

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.

Subunit:

Interacts with MAP3K14/NIK.

Subcellular Location:

Nucleus.

Tissue Specificity:

Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.

Similarity:

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 5 C2H2-type zinc fingers.

SWISS:

Q96JP5

Gene ID:

80829