XKR1抗体

XKR1抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-7640R

英文名称XKR1

中文名称膜转运蛋白XK抗体

别    名XK; Kell complex 37 kDa component; Membrane transport protein XK; XK related protein 1; XKR1; XRG1.  

说 明 书100ul  200ul

研究领域心血管  细胞生物  转运蛋白  

抗体来源Rabbit

克隆类型Polyclonal

XKR1抗体交叉反应 Human, Mouse, Rat, Chicken,

产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量49kDa

细胞定位细胞膜

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human XKR1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

XK is the Kell blood group 'precursor substance'. This protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. The Kell blood group is constituted by two covalently linked antigens at the surface of red blood cells, Kell and KX. Whereas Kell is a metalloprotease with demonstrated in vitro enzymatic activity, the role of KX thereon, and/or alone, remains unknown, although its absence is linked to the McLeod syndrome, a neuroacanthocytosis. KX appears to be required for proper synthesis or presentation of the Kell antigens on the red blood cell surface.

Function:

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides

Subunit:

Heterodimer with Kell; disulfide-linked.

Subcellular Location:

Membrane; Multi-pass membrane protein (Potential).

Tissue Specificity:

High levels in skeletal muscle, heart, brain,

DISEASE:

Defects in XK are the cause of McLeod syndrome (MLS) [MIM:300842]. It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems.

Similarity:

Belongs to the XK family.

Gene ID:

7504