WRCH1抗体

WRCH1抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-1944R

英文名称WRCH1

中文名称WRCH1抗体

别    名WRCH-1; WRCH 1; Wnt-1 responsive Cdc42 homolog 1; Rho-related GTP-binding protein RhoU; Ryu GTPase; CDC42-like GTPase 1; Rho GTPase-like protein ARHU; GTP-binding protein-like 1; RHOU; SB128; ARHU; CDC42L1; G28K; WRCH1; RHOU_HUMAN.  

说 明 书100ul  200ul

研究领域细胞生物  信号转导  激酶和磷酸酶  

抗体来源Rabbit

克隆类型Polyclonal

WRCH1抗体交叉反应 Human, Mouse, Rat, Cow, Rabbit,

产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量29kDa

细胞定位细胞浆 细胞膜

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human WRCH-1

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

The WRCH1 protein is a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation.

Function:

Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Subunit:

Interacts with PAK3.

Subcellular Location:

Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells.

Tissue Specificity:

Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta.

Post-translational modifications:

Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation.

Similarity:

Belongs to the small GTPase superfamily. Rho family.

Gene ID:

58480