TRF4-2抗体

TRF4-2抗体经ICC, IHC严格验证,品质保证.适用于多种种属反应性,被多篇文献引用并有用户反馈信息.确保特异性!产品具有以下特点:

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产品编号xy-16715R

英文名称TRF4-2

中文名称拓扑异构酶相关功能蛋白4-2抗体

别    名PAP-associated domain-containing protein 5; Terminal uridylyltransferase 3; Topoisomerase related function protein 4-2; TRF4-2; PAPD5_HUMAN; TUTase 3.  

说 明 书100ul  200ul

研究领域转录调节因子  表观遗传学  

抗体来源Rabbit

克隆类型Polyclonal

TRF4-2抗体交叉反应 Human,

产品应用ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量63kDa

细胞定位细胞核

性    状Lyophilized or Liquid

浓    度1mg/1ml

免 疫 原KLH conjugated synthetic peptide derived from human TRF4-2

亚    型IgG

纯化方法affinity purified by Protein A

储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

PubMedPubMed

产品介绍background:

Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion

Function:

Catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion.

Subunit:

Component of a nucleolar TRAMP-like complex, an ATP-dependent exosome regulatory complex consisting of an helicase

Subcellular Location:

Nuclear

Similarity:

Belongs to the DNA polymerase type-B-like family.

Contains 1 PAP-associated domain.

Gene ID:

64282