产品详情
查看大图

  • 产品名称：α-Conotoxin PIA

  • 产品型号：CON023
  • 产品厂商：
  • 产品价格：0
  • 折扣价格：0
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
详情介绍：
α-Conotoxin PIA α-conotoxin PIA has been isolated from the venom of the marine snail Conus purpurascens. α-conotoxin PIA preferentially targets neuronal AChR subtypes containing α6 subunits. The peptide displays 75-fold higher affinity for rat α6/α3β2β3 nAChRs over rat α3β2 nAChRs. α-conotoxin PIA potently inhibits human chimeric α6/α3β2β3 nAChRs (IC50 of 1.7 nM) and provided similar results on rat chimeric α6/α3β2β3 (IC50 of 0.95 nM). 10 μM α-conotoxin PIA has no effect on the ***** form of the human muscle nAChR demonstrating a high specificity for α6-containing neuronal nAChRs. The peptide has no effect on α2- and α4-containing neuronal nAChRs. α6-containing neuronal nAChRs are highly expressed in several catecholaminergic nuclei (locus coeruleus, ventral tegmental area and substantia nigra), play a significant role in nicotinic reward and dependence, and is a therapeutic target of interest in Parkinson disease.
标题：
内容：
联系人：
联系电话：
Email：
公司名称：
联系地址：
 
 
注：1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!
2.如有必要,请您留下您的详细联系方式!
相关文章

沪公网安备 31011202007343号