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  • 产品名称：GPSM2, Blocking Peptide

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简单介绍：
GPSM2, Blocking Peptide
详情介绍：
Product Name

GPSM2, Blocking Peptide

Full Product Name

GPSM2 Immunizing Peptide

Product Synonym Names
GPSM2; G-protein signalling modulator 2 (AGS3-like, C. elegans); HGNC: 29501; LGN; Pins; LGN protein
Product Gene Name

GPSM2 blocking peptide

[Similar Products]
Antibody/Peptide Pairs
GPSM2 peptide (MBS426838) is used for blocking the activity of GPSM2 antibody (MBS421246)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence
C-NRLKGKKY KTNSSTK
OMIM
604213
Species Reactivity
Human, Dog
Form/Format
100ug of dried peptide
Preparation and Storage
Shipped at ambient temperature, store at -20 degree C
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of GPSM2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for GPSM2. It may not necessarily be applicable to this product.
NCBI GI #
31543053
NCBI GeneID
29899
NCBI Accession #
NP_037428.2 [Other Products]
NCBI GenBank Nucleotide #
NM_013296.3 [Other Products]
UniProt Secondary Accession #
Q5T1N8; Q6IBL7; Q8N0Z5[Other Products]
UniProt Related Accession #
P81274[Other Products]
Molecular Weight
76,662 Da
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NCBI Official Full Name
G-protein signaling modulator 2 (AGS3-like, C. elegans)
NCBI Official Synonym Full Names
G-protein signaling modulator 2
NCBI Official Symbol
GPSM2  [Similar Products]
NCBI Official Synonym Symbols
LGN; CMCS; PINS; DFNB82
  [Similar Products]
NCBI Protein Information
G-protein-signaling modulator 2
UniProt Protein Name
G-protein-signaling modulator 2
UniProt Synonym Protein Names
Mosaic protein LGN
Protein Family
G-protein-signaling modulator
UniProt Gene Name
GPSM2  [Similar Products]
UniProt Synonym Gene Names
LGN  [Similar Products]
UniProt Entry Name
GPSM2_HUMAN
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NCBI Summary for GPSM2
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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UniProt Comments for GPSM2
GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: apical part of cell; cell cortex; cytoplasm

Molecular Function: G-protein alpha-subunit binding; GDP-dissociation inhibitor activity; identical protein binding; nucleotide binding; protein binding

Biological Process: establishment of mitotic spindle orientation; G-protein coupled receptor protein signaling pathway; maintenance of centrosome localization; mitotic spindle organization and biogenesis; regulation of catalytic activity

Disease: Chudley-mccullough Syndrome
Research Articles on GPSM2
1. A crystal structure of Frmpd4-bound LGN in an oxidized form is also reported, although oxidation does not appear to strongly affect the interaction with Frmpd4.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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