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  • 产品名称：GPSM2, Polyclonal Antibody

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简单介绍：
GPSM2, Polyclonal Antibody
详情介绍：
Product Name

GPSM2, Polyclonal Antibody

Full Product Name

GPSM2 Polyclonal Antibody

Product Synonym Names
LGN; CMCS; PINS; DFNB82
Product Gene Name

anti-GPSM2 antibody

[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
phenotype 609245
3D Structure
ModBase 3D Structure for P81274
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Species
Human
Immunogen
Recombinant Protein
Immunogen
Recombinant protein of human GPSM2
Calculated Molecular Weight
75kDa
Preparation and Storage
Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Notes
Small volumes of anti-GPSM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-GPSM2 antibody
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).
Product Categories/Family for anti-GPSM2 antibody
Polyclonal
Applications Tested/Suitable for anti-GPSM2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-GPSM2 antibody
WB: 1:200-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-GPSM2 antibody
Western blot analysis of extracts of A-431 cells, using GPSM2 antibody.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-GPSM2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for GPSM2. It may not necessarily be applicable to this product.
NCBI GI #
294862507
NCBI GeneID
29899
NCBI Accession #
P81274.3 [Other Products]
UniProt Primary Accession #
P81274 [Other Products]
UniProt Secondary Accession #
Q5T1N8; Q6IBL7; Q8N0Z5[Other Products]
UniProt Related Accession #
P81274[Other Products]
Molecular Weight
684
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NCBI Official Full Name
G-protein-signaling modulator 2
NCBI Official Synonym Full Names
G-protein signaling modulator 2
NCBI Official Symbol
GPSM2  [Similar Products]
NCBI Official Synonym Symbols
LGN; CMCS; PINS; DFNB82
  [Similar Products]
NCBI Protein Information
G-protein-signaling modulator 2; mosaic protein LGN; G-protein signalling modulator 2 (AGS3-like, C. elegans)
UniProt Protein Name
G-protein-signaling modulator 2
UniProt Synonym Protein Names
Mosaic protein LGN
Protein Family
G-protein-signaling modulator
UniProt Gene Name
GPSM2  [Similar Products]
UniProt Synonym Gene Names
LGN  [Similar Products]
UniProt Entry Name
GPSM2_HUMAN
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NCBI Summary for GPSM2
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).[provided by RefSeq, Jan 2011]
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UniProt Comments for GPSM2
GPSM2: Plays an important role in spindle pole orientation. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions. Interacts with LLGL2. Interacts with INSC/inscuteable and probably with F2RL2. Ubiquitously expressed. Belongs to the GPSM family.

Protein type: G protein regulator, misc.

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: apical part of cell; cytoplasm; cell cortex

Molecular Function: identical protein binding; protein binding; GTPase regulator activity

Biological Process: G-protein coupled receptor protein signaling pathway; establishment of mitotic spindle orientation; regulation of catalytic activity

Disease: Chudley-mccullough Syndrome
Research Articles on GPSM2
1. LGN is required for mitotic spindle rotation but not orientation maintenance.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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