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  • 产品名称：LGN, Polyclonal Antibody

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简单介绍：
LGN, Polyclonal Antibody
详情介绍：
Product Name

LGN, Polyclonal Antibody

Full Product Name

Anti-LGN Antibody

Product Synonym Names
LGN; G-protein-signaling modulator 2; Mosaic protein LGN
Product Gene Name

anti-LGN antibody

[Similar Products]
Product Synonym Gene Name
GPSM2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
U54999 mRNA
3D Structure
ModBase 3D Structure for P81274
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of LGN protein.
Purity/Purification
Purified by immunogen affinity chromatography
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human LGN
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-LGN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-LGN antibody
Rabbit polyclonal antibody to LGN
Applications Tested/Suitable for anti-LGN antibody
Western Blot (WB)
Application Notes for anti-LGN antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-LGN antibody
Western blot analysis of LGN expression in Hela (A), mouse brain (B), mouse liver (C) whole cell lysates.
anti-LGN antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for LGN. It may not necessarily be applicable to this product.
NCBI GI #
1005136639
NCBI GeneID
29899
NCBI Accession #
NP_001307967.1 [Other Products]
NCBI GenBank Nucleotide #
NM_001321038.1 [Other Products]
UniProt Primary Accession #
P81274 [Other Products]
UniProt Secondary Accession #
Q5T1N8; Q6IBL7; Q8N0Z5[Other Products]
UniProt Related Accession #
P81274[Other Products]
Molecular Weight
76,662 Da
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NCBI Official Full Name
G-protein-signaling modulator 2
NCBI Official Synonym Full Names
G protein signaling modulator 2
NCBI Official Symbol
GPSM2  [Similar Products]
NCBI Official Synonym Symbols
LGN; CMCS; PINS; DFNB82
  [Similar Products]
NCBI Protein Information
G-protein-signaling modulator 2
UniProt Protein Name
G-protein-signaling modulator 2
UniProt Synonym Protein Names
Mosaic protein LGN
UniProt Gene Name
GPSM2  [Similar Products]
UniProt Synonym Gene Names
LGN  [Similar Products]
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NCBI Summary for LGN
The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
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UniProt Comments for LGN
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Plays also an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity ().
Research Articles on LGN
1. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and LGN in fine-tuning TRPC4 activities.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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