VEGF-C HSS-0726 合肥星肽生物科技有限公司

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产品名称：VEGF-C
产品型号：HSS-0726
产品展商：其它品牌

产品价格：0.00 元

产品文档：无相关文档
发布时间：2021-08-24
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简单介绍

VEGFC,Flt4-L,VRP

产品描述

Vascular endothelial growth factor C is also known as VEGFC, Flt4-L and VRP, it contains the C-terminal propeptide which has an unusual structure with tandemly repeated cysteine-rich motifs. Upon biosynthesis, VEGFC is secreted as a non-covalent momodimer in an anti-parellel fashion. VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. The structure and function of this protein is similar to those of vascular endothelial growth factor D (VEGF-D). VEGFC may function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in *****s. Overexpression of VEGF-C causes lymphatics to enlarge possibly facilitates metastasis.

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