iC3b is generated during the activation of the complement system via the classical or alternative pathway. When a convertase enzyme cleaves C3, C3a and C3b are released in parallel. In vivo, the C3b molecule has a very short half life; C3b is rapidly cleaved to iC3b which can serve as a marker for complement activation by the alternative or classical pathway.
All Quidel complement components are tested for functional activity in a standard lytic or applicable functional ***** and for biochemical purity by SDS-polyacrylamide gel electrophoresis. Please refer to the Certificate of Analysis for lot specific information on functional titer.
Quidel iC3b Protein
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