描述

MK-2461是一种ATP竞争性的 c-Met 抑制剂, 平均 IC50 为2.5 nM。

相关类别

信号通路 >> 蛋白酪氨酸激酶 >> c-Met的/HGFR

研究领域 >> 癌症

参考文献

[1]. Pan BS, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70(4):1524-33.

密度

1.5±0.1 g/cm3

沸点

732.4±70.0 °C at 760 mmHg

分子式

C24H25N5O5S

分子量

495.551

闪点

396.7±35.7 °C

精*确质量

495.157654

PSA

124.03000

LogP

-0.52

蒸汽压

0.0±2.4 mmHg at 25°C

折射率

1.693

Sulfamide, N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-

MK-2461

cc-600

UNII-4200RD53XF

N-[(2R)-1,4-Dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfuric diamide

Sulfamide,N-((2R)-1,4-dioxan-2-ylmethyl)-N-methyl-N'-(3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)