名称：重组人OGG1/N-glycosylase/DNA lyaseProtein（N-GST）；
产品说明(Description) Recombinant Human N-Glycosylase is produced by our E.coli expression system and the target gene encoding Met1-Gly345 is expressed with a GST tag at the N-terminus. Accession #: O15527 Known as: N-Glycosylase/DNA Lyase; 8-Oxoguanine DNA Glycosylase; DNA-(Apurinic or Apyrimidinic Site) Lyase; AP Lyase; OGG1; MMH; MUTM; OGH1 制剂（Formulation） Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 100mM NaCl, 1mM DTT, 1mM EDTA, 50% Glycerol, pH 7.8. 质量控制（Quality Control） Purity:Greater than 95% as determined by reducing SDS-PAGE. Endotoxin:Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
复溶（Reconstitution）
保存（Storage） Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
背景（Background） Human N-Glycosylase/DNA Lyase(OOG1) is a DNA repair enzyme, which belongs to the type-1 OGG1 family. OOG1 incises DNA at 8-oxoG residues, and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damage DNA. It has a β-lyase activity that nicks DNA 3’ to the lesion. OOG1 together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells. The OGG1 gene mutations may be caused Renal cell carcinoma. 电泳(SDS-PAGE) FOR RESEARCH USE ONLY