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英文名称： Anti-Rasgrf1(Phospho-Ser916) rabbit polyclonal antibody
别 名： GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1
相关类别： 一抗
储 存： 冷冻（-20℃） 避光
宿 主： Rabbit
抗 原： Rasgrf1(Phospho-Ser916)
标 记 物： Unconjugate
克隆类型： rabbit polyclonal
技术规格
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Background: |
Ras activity is regulated by GAP (GTPase activating proteins) and GEFs (guanine nucleotide exchange factors). Ras-GRF1 (also known as CDC25Mm) is neuronal RasGEF and is regulated by heterotrimeric G proteins and calcium influx . Binding to calmodulin and phosphorylation stimulate Ras-GRF1 activity. Multiple PKA phosphorylation sites on Ras-GRF have been identified. Phosphorylation on the two major sites, Ser54 and Ser822, inhibits Ras-GRF activity. Carbachol (a muscarinic agonist)-induced phosphorylation on Ser916 is essential but not sufficient for maximal Ras-GRF activity. |
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Applications: |
IHC |
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Name of antibody: |
Rasgrf1(Phospho-Ser916) |
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Immunogen: |
Peptide sequence around phosphorylation site of Serine 916(N-E-G(p)-T P) derived from Human Ras-GRF1. |
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Full name: |
Ras protein-specific guanine nucleotide-releasing factor 1 |
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Synonyms： |
GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1 |
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SwissProt: |
Q13972 |
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IHC positive control: |
Human brain tissue |
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IHC Recommend dilution: |
50-100 |
