中文名称： C4BPB 抗原（重组蛋白）
英文名称： C4BPB Antigen (Recombinant Protein)
别 名： complement component 4 binding protein beta; C4BP
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
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Fusion protein corresponding to a region derived from 21-251 amino acids of human C4BPB |
技术规格
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Full name: |
complement component 4 binding protein beta |
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Synonyms: |
C4BP |
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Swissprot: |
P20851 |
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Gene Accession: |
BC005378 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. |
