英文名称： CDC45 Antigen (Recombinant Protein)
别 名： cell division cycle 45; CDC45L; CDC45L2; PORC-PI-1
储 存： 冷冻（-20℃）
相关类别： 抗原
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Full name: |
cell division cycle 45 |
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Synonyms: |
CDC45L; CDC45L2; PORC-PI-1 |
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Swissprot: |
O75419 |
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Gene Accession: |
BC006232 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. |
