- 入驻时间： 2020-07-28
- 联系人：王珺茹
- 电话：021-54845833
-
联系时，请说明易展网看到的
- Email：2881498548@qq.com
别 名： mitogen-activated protein kinase-activated protein kinase 5; MK5; MK-5; PRAK; MAPKAP-K5
储 存： 冷冻（-20℃）
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Full name: |
mitogen-activated protein kinase-activated protein kinase 5 |
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Synonyms: |
MK5; MK-5; PRAK; MAPKAP-K5 |
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Swissprot: |
Q8IW41 |
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Gene Accession: |
BC041049 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. |
