- 入驻时间： 2020-07-28
- 联系人：王珺茹
- 电话：021-54845833
-
联系时，请说明易展网看到的
- Email：2881498548@qq.com
英文名称： CASR Antigen (Recombinant Protein)
别 名： calcium sensing receptor; CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
储 存： 冷冻（-20℃）
相关类别：抗原
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Full name: |
calcium sensing receptor |
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Synonyms: |
CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1 |
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Swissprot: |
P41180 |
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Gene Accession: |
BC112236 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. |
