CUE结构域蛋白1抗体

CUE结构域蛋白1抗体

英文名称：CUEDC1

中文名称：CUE结构域蛋白1抗体

别    名；CUE domain containing protein 1; CUED1_HUMAN.

研究领域；  细胞生物

抗体来源；Rabbit

克隆类型；Polyclonal

交叉反应；(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Zebrafish, Sheep, )

产品应用；WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量；42kDa

细胞定位；细胞核 细胞浆

性    状；Liquid

浓    度；1mg/ml

免 疫 原；KLH conjugated synthetic peptide derived from human CUEDC1: 251-350/386

亚    型；IgG

纯化方法；affinity purified by Protein A

缓 冲 液；0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件；Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍：

The coupling of ubiquitin conjugation to endoplasmic reticulum (ER) degradation (CUE) domain functions as a ubiquitin (UB) binding domain that is approximately 40 amino acids in length. Present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways, CUE domains can bind monoubiquitin and may be required for ubiquitination of the proteins in which they are found. CUEDC1 (CUE domain-containing protein 1) is a 386 amino acid protein that contains one CUE domain, suggesting a possible role in protein trafficking and degradation pathways. Defects in the gene encoding CUEDC1 may be associated with early stage cervical cancer, implicating CUEDC1 as a potential tumor marker. Two isoforms of CUEDC1 exist due to alternative splicing events.

一抗操作步骤：

洗涤：‌洗涤的目的是为了洗去一抗的非特异性结合，‌洗涤的效果直接影响结果背景的深浅。‌建议使用PBST或TBST作为洗涤液，‌其中的Tween20有助于去除非特异性的结合，‌减少背景。‌洗涤的次数和时间根据具体实验来确定，‌建议清洗3-5次，‌每次5分钟。‌

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