DBCO NHS ester

NHS esters Alkynes Copper free Click chemistry Cycloalkyne Protein labeling

Cat. #	Quantity	Price	Lead time
34720	10 mg	60.00$	5 days
44720	25 mg	95.00$	in stock
54720	50 mg	145.00$	in stock
64720	100 mg	210.00$	in stock
94720	1 g	1190.00$	in stock

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Dibenzocyclooctyne (ADIBO, DBCO) is one of the most reactive cycloalkynes for strain promoted alkyne azide cycloaddition (spAAC) – a copper free Click chemistry reaction.

This is an amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.

DBCO reacts instantly with azides. The rate of the reaction is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike some other cyclooctynes, DBCO does not react with tetrazines - this allows to carry out orthogonal conjugation of azides with DBCO, and trans-cyclooctenes with tetrazines.

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General properties

Appearance:	off white solid
Mass spec M+ increment:	315.1
Molecular weight:	430.45
Molecular formula:	C25H22N2O5
IUPAC name:	6-{2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}-6-oxohexanamide
Solubility:	good in DCM, DMF, DMSO
Quality control:	NMR 1H, HPLC-MS (95%)
Storage conditions:	Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download