TFA-Amino modifier CPG 500

Oligonucleotide synthesis

Cat. #	Quantity	Price	Lead time
11860	100 mg	60.00$	in stock
21860	250 mg	120.00$	in stock
31860	500 mg	230.00$	in stock
41860	1 g	380.00$	in stock
51860	5 g	1450.00$	21 days

Bulk inquiry

This high load, 500 ? controlled pore glass solid support is designed for the synthesis of oligonucleotides containing up to 50 bases with a 3'-amino group. Amino group is protected with trifluoroacetyl (TFA) protection which is easily removed under standard deblock conditions.

The reagent is based on hydroxyprolinol core - a universal non-nucleoside structure that is naturally 100% chiral (no isomers formed upon condensation), and stable to all conditions of oligonucleotide synthesis and deblock.

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General properties

Appearance:	off-white beads
Quality control:	NMR 1H and HPLC-MS (95%) of bound reagent, loading measurement
Storage conditions:	Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download

Oligo synthesis details

Pore size, ?:	500
Typical loading, umol/g:	70?90
Coupling conditions:	standard coupling, identical to normal nucleobases
Cleavage conditions:	ammonia, 2 h at room temperature
Deprotection conditions:	identical to protected nucleobases

Product citations

Taskova, M.; Uhd, J.; Miotke, L.; Kubit, M.; Bell, J.; Ji, H.P.; Astakhova, K. Tandem Oligonucleotide Probe Annealing and Elongation To Discriminate Viral Sequence. Analytical Chemistry, 2017, 89(8), 4363–4366. doi: 10.1021/acs.analchem.7b00646