signalchemlifesciences
signalchemlifesciences公司 signalchemlifesciences代理 signalchemlifesciences中国代理 signalchemlifesciences**代理
SignalChem Lifesciences Corporation（SLC）是一家在加拿大不列颠哥伦比亚省注册的生物技术公司。它有两个业务部门：生物试剂和服务业务以及药物发现和开发业务。SignalChem Pharmaceuticals Inc（SCP）于2004年成立时开始了生物试剂和服务业务.SCP*初专注于生产激酶相关产品以促进生物医学研究和药物研发工作。该公司目前的产品线已经超过了2000个，涵盖了整个激酶组织的几乎所有的激酶靶标以及测定，表观遗传酶和测定，其他信号转导蛋白质，工具和服务等。生物试剂业务创造的产品为SLC寻求快速，经济高效地创造新型候选药物提供了显着的优势，而这一创收业务已成为公司药物发现平台的基础。
公司的主要产及服务包括：
1、凭借公司强大的科研力量和经验，SignalChem推出的“Kinome Search Engine”激酶筛选系统，可对每一个激酶族中的单个激酶做出检测，从而辅助和加快激酶药物的研发。
2、“Kinome Search Engine”激酶筛选系统不仅可辅助设计激酶药物，还可进一步研究人类激酶族的功能和机制，加深对未知激酶的认识，寻找更多的药物靶点，（目前认证的药物仅仅有少于5%是以已知的激酶通路为靶点，因此激酶通路作为药物靶点有着巨大的潜力和价值）。
3、SignalChem公司拥有激酶相关**突变数据库，在研究疾病复发和抗药领域的核心问题时有着****的优势，可以更为有效地协助制药企业进行药物研发。
除了药物研发方面的优势，SignalChem还在生物标志物及诊断试剂盒领域有着数十年的积淀，拥有强大和丰富的相关产品。
目前SLC公司的产品覆盖了几乎所有细胞内激酶相关通路，包括AKT/PKB通路、ERK/MAPK通路、JAK/STAT通路、JNK/SAPK通路、NfkB通路、p38通路、PKA/PKC通路、WNT信号通路等，适用于血管再生、凋亡和自噬、肿瘤、心血管疾病、细胞周期、细胞应激、胞内酪氨酸激酶、炎症、浸润和转移、脂质激酶、代谢性疾病、神经生物学、磷酸酶/磷酸二酯酶、受体酪氨酸激酶、Ser/Thr激酶等研究领域。主要产品有：
一、蛋白酶类产品系列
1、高活性乙酰转移酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
KAT2A (GCN5), Active |
K311-381G |
Human |
GST tag |
Sf9 insect cells |
323-end |
NM_021078 |
|
KAT2B (PCAF), Active |
K311-381BG |
Human |
GST tag |
Sf9 insect cells |
431-end |
NM_003884 |
|
KAT3A (CREBBP), Active |
K312-381G |
Human |
GST tag |
Sf9 insect cells |
1319-1710 |
NM_004380 |
|
KAT5 (TIP60), Active |
K314-380G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_006388 |
|
KAT6B (MYST4), Active |
K315-381BG |
Human |
GST tag |
Sf9 insect cells |
431-end |
NM_012330 |
|
KAT7 (MYST2), Active |
K316-380G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_007067 |
2、高活性精氨酸脱亚氨酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
PAD Cocktail, Active |
P312-37C |
- |
- |
- |
Full Length |
- |
3、高活性GTP/ATP酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
CDC42, Active |
C108-310GH |
Human |
GST/His |
E.coli |
Full length |
NM_001791 |
|
GNAI1, Active |
G121-310G |
Human |
GST tag |
E.coli |
2-end |
NM_002069 |
|
GNAI2, Active |
G122-310G |
Human |
GST tag |
E.coli |
2-end |
NM_002070 |
|
GNAI3, Active |
G123-310G |
Human |
GST tag |
E.coli |
2-end |
NM_006496 |
|
GNAS, Active |
G127-310G |
Human |
GST tag |
E.coli |
Full length |
NM_000516 |
|
HRAS1 (Mature form), Active |
R105-310H |
Human |
His tag |
E.coli |
2-186 |
NM_005343 |
|
KRAS (Mature form), Active |
R106-310H |
Human |
His tag |
E.coli |
2-186 |
NM_033360 |
|
NRAS (Mature form), Active |
R107-310H |
Human |
His tag |
E.coli |
2-186 |
NM_002524 |
|
RAC1, Active |
R103-310G |
Human |
GST tag |
E.coli |
Full length |
NM_006908 |
|
RAC2, Active |
R104-310H |
Human |
His tag |
E.coli |
Full length |
NM_002872 |
|
RAC3, Active |
R102-310H |
Human |
His tag |
E.coli |
Full length |
NM_005052 |
|
RhoA (Mature form), Active |
R144-310H |
Human |
His tag |
E.coli |
1-190 |
NM_001664 |
|
RhoC (Mature form), Active |
R144-310CH |
Human |
His tag |
E.coli |
1-190 |
NM_175744 |
|
RhoD (Mature form), Active |
R144-310DH |
Human |
His tag |
E.coli |
1-207 |
BC001338 |
|
VCP, Active |
V116-310G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_007126 |
4、高活性组蛋白去乙酰化酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
HDAC1, Active |
H83-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_004964 |
|
HDAC10, Active |
H92-31G |
Human |
GST tag |
Sf9 insect cells |
1-482 |
NM_032019 |
|
HDAC11, Active |
H93-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_024827 |
|
HDAC2, Active |
H84-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_001527 |
|
HDAC3, Active |
H85-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_003883 |
|
HDAC3/NCOR2, Active |
H85-38G |
Human |
GST tags |
Sf9 insect cells |
HDAC3 (full-length)/ NCOR2 (237-489) |
NM_003883 |
|
HDAC4, Active |
H86-31G |
Human |
GST tag |
Sf9 insect cells |
612-end |
NM_006037 |
|
HDAC5, Active |
H87-31G |
Mouse |
GST tag |
Sf9 insect cells |
617-end |
BC060609 |
|
HDAC6, Active |
H88-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
BC069243 |
|
HDAC7, Active |
H89-31G |
Human |
GST tag |
Sf9 insect cells |
501-end |
NM_015401 |
|
HDAC8, Active |
H90-30H |
Human |
His tag |
Sf9 insect cells |
Full Length |
BC050433 |
5、活性突变激酶（共计253种）
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
ABL1 Mutant (E255K), Active |
A03-12BG |
Human |
GST tag |
Sf9 insect cells |
27-end (E255K) |
NM_005157 |
|
ABL1 Mutant (E255V), Active |
A03-12HH |
Human |
His tag |
Sf9 insect cells |
27-end (E255V) |
NM_005157 |
|
ABL1 Mutant (F317I), Active |
A03-12JG |
Human |
GST tag |
Sf9 insect cells |
27-end (F317I) |
NM_005157 |
|
ABL1 Mutant (F317L), Active |
A03-12IG |
Human |
GST tag |
Sf9 insect cells |
27-end (F317L) |
NM_005157 |
|
ABL1 Mutant (G250E), Active |
A03-12CG |
Human |
GST tag |
Sf9 insect cells |
27-end (G250E) |
NM_005157 |
|
ABL1 Mutant (H396P), Active |
A03-12LG |
Human |
GST tag |
Sf9 insect cells |
27-end (H396P) |
NM_005157 |
|
ABL1 Mutant (M351T), Active |
A03-12KG |
Human |
GST tag |
Sf9 insect cells |
27-end (M351T) |
NM_005157 |
|
ABL1 Mutant (Q252H), Active |
A03-12FG |
Human |
GST tag |
Sf9 insect cells |
27-end (Q252H) |
NM_005157 |
|
ABL1 Mutant (T315I), Active |
A03-12DG |
Human |
GST tag |
Sf9 insect cells |
27-end (T315I) |
NM_005157 |
|
ABL1 Mutant (V299L), Active |
A03-12MG |
Human |
GST tag |
Sf9 insect cells |
27-end (V299L) |
NM_005157 |
|
ABL1 Mutant (Y253F), Active |
A03-12EG |
Human |
GST tag |
Sf9 insect cells |
27-end (Y253F) |
NM_005157 |
|
ABL1 Mutant (Y253H), Active |
A03-12GH |
Human |
His tag |
Sf9 insect cells |
27-end (Y253H) |
NM_005157 |
|
AKT1 Mutant (E17K), Active |
A16-12G |
Human |
GST tag |
Sf9 insect cells |
Full length (E17K) |
NM_005163 |
|
AKT2 Mutant (E17K), Active |
A17-12G |
Human |
GST tag |
Sf9 insect cells |
Full length (E17K) |
NM_001626 |
|
AKT2 Mutant (R274H), Active |
A17-12BG |
Human |
GST tag |
Sf9 insect cells |
Full length (R274H) |
NM_001626 |
|
AKT3 Mutant (E17K), Active |
A18-12G |
Human |
GST tag |
Sf9 insect cells |
Full Length (E17K) |
NM_005465 |
|
AKT3 Mutant (G171R), Active |
A18-12BG |
Human |
GST tag |
Sf9 insect cells |
Full length (G171R) |
NM_005465 |
|
ALK Mutant (C1156Y), Active |
A19-12DG |
Human |
GST tag |
Sf9 insect cells |
1060-end (C1156Y) |
NM_004304 |
|
ALK Mutant (F1174L), Active |
A19-12EG |
Human |
GST tag |
Sf9 insect cells |
1060-end (F1174L) |
NM_004304 |
|
ALK Mutant (F1174S), Active |
A19-12FG |
Human |
GST tag |
Sf9 insect cells |
1060-end (F1174S) |
NM_004304 |
|
ALK Mutant (G1202R), Active |
A19-12HG |
Human |
GST tag |
Sf9 insect cells |
1060-end (G1202R) |
NM_004304 |
|
ALK Mutant (G1269A), Active |
A19-12JG |
Human |
GST tag |
Sf9 insect cells |
1060-end (G1269A) |
NM_004304 |
|
ALK Mutant (G1269S), Active |
A19-12KG |
Human |
GST tag |
Sf9 insect cells |
1060-end (G1269S) |
NM_004304 |
|
ALK Mutant (L1152R), Active |
A19-12CG |
Human |
GST tag |
Sf9 insect cells |
1060-end (L1152R) |
NM_004304 |
|
ALK Mutant (L1196M), Active |
A19-12GG |
Human |
GST tag |
Sf9 insect cells |
1060-end (L1196M) |
NM_004304 |
|
ALK Mutant (R1275Q), Active |
A19-12LG |
Human |
GST tag |
Sf9 insect cells |
1060-end (R1275Q) |
NM_004304 |
|
ALK Mutant (S1206R), Active |
A19-12IG |
Human |
GST tag |
Sf9 insect cells |
1060-end (S1206R) |
NM_004304 |
|
ALK Mutant (T1151M), Active |
A19-12BG |
Human |
GST tag |
Sf9 insect cells |
1060-end (T1151M) |
NM_004304 |
|
ALK Mutant (T1151_L1152insT), Active |
A19-12G |
Human |
GST tag |
Sf9 insect cells |
1060-end (T1151_L1152insT) |
NM_004304 |
|
ALK2 Mutant (PF197_198L), Active |
A06-12FG |
Human |
GST tag |
Sf9 insect cells |
147-end (PF197_198L) |
NM_001105 |
|
ALK2 Mutant (Q207D), Active |
A06-13CG |
Human |
GST tag |
Sf9 insect cells |
147-end (Q207D) |
NM_001105 |
|
ALK2 Mutant (Q207E), Active |
A06-13DG |
Human |
GST tag |
Sf9 insect cells |
147-end (Q207E) |
NM_001105 |
|
ALK2 Mutant (R206H), Active |
A06-12BG |
Human |
GST tag |
Sf9 insect cells |
147-end (R206H) |
NM_001105 |
|
ALK3 Mutant (Q233D), Active |
B04-12BG |
Human |
GST tag |
Sf9 insect cells |
187-end (Q233D) |
NM_004329 |
|
ALK3 Mutant (R486Q), Active |
B04-12CG |
Human |
GST tag |
Sf9 insect cells |
187-end (R486Q) |
NM_004329 |
|
AXL Mutant (R499C), Active |
A34-12BG |
Human |
GST tag |
Sf9 insect cells |
473-end (R499C) |
NM_021913 |
|
BCR-RET Mutant, Active |
R02-19EG |
Human |
GST tag |
Sf9 insect cells |
1-426 (BCR) - 713-end (RET) |
BC066122 |
|
BRAF Mutant (d485-489 P490Y), Active |
B08-12IG |
Human |
GST tag |
Sf9 insect cells |
381-end or exon 9-18 (d485-489 P490Y) |
NM_004333 |
|
BRAF Mutant (G464V), Active |
B08-12JG |
Human |
GST tag |
Sf9 insect cells |
381-end or exon 9-18 (G464V) |
NM_004333 |
|
BRAF Mutant (G469A), Active |
B08-12FG |
Human |
GST tag |
Sf9 insect cells |
381-end or exon 9-18 (G469A) |
NM_004333 |
|
BRAF Mutant (K601E), Active |
B08-12BG |
Human |
GST tag |
Sf9 insect cells |
416-end (K601E) |
NM_004333 |
|
BRAF Mutant (L597V), Active |
B08-12HG |
Human |
GST tag |
Sf9 insect cells |
381-end or exon 9-18 (L597V) |
NM_004333 |
|
BRAF Mutant (R506_K507insVLR), Active |
B08-13CG |
Human |
GST tag |
Sf9 insect cells |
381-end or exon 9-18 (R506_K507insVLR) |
NM_004333 |
6、活性激酶
该产品系列共包括445种激酶产品，下表仅列部分.
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
ABL1, Active |
A03-11H |
Mouse |
His tag |
Sf9 insect cells |
27-end |
NM_009594 |
|
ABL1, Active |
A03-18H |
Human |
His tag |
Sf9 insect cells |
27-end |
NM_005157 |
|
ABL2, Active |
A04-11H |
Human |
His tag |
Sf9 insect cells |
38-end |
NM_005158 |
|
ACK, Active |
A05-11G |
Human |
GST tag |
Sf9 insect cells |
110-476 |
NM_005781 |
|
AKT1, Active |
A16-10G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_005163 |
|
AKT2, Active |
A17-10H |
Human |
His tag |
Sf9 insect cells |
Full Length |
NM_001626 |
|
AKT2, Active |
A17-10G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_001626 |
|
AKT3, Active |
A18-10G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_005465 |
7、高活脂质激酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
DGKA, Active |
D21-10G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_001345 |
|
PI3K (p110 alpha (E545K)/p85 alpha), Active |
P27-152H |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha (N345K(/p85 alpha), Active |
P27-122CH |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha(E542K)/p85 alpha, Active |
P27-122DH |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha/p55 gamma), Active |
P27-102CH |
Human |
His tag |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha/p85 alpha), Active |
P27-102G |
Human |
GST tags |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha/p85 alpha), Active |
P27-102H |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006218 |
|
PI3K (p110 alpha/p85 alpha), Active |
P27-182H |
Mouse |
His tags |
Sf9 insect cells |
Full length |
NM_008839 |
|
PI3K (p110 beta/p85 alpha), Active |
P28-102H |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006219 |
|
PI3K (p110 beta/p85 beta), Active |
P28-102BH |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_006219 |
|
PI3K (p110 delta/p85 alpha), Active |
P30-102H |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_005026 |
|
PI3K (p120 gamma), Active |
P29-102H |
Human |
His tag |
Sf9 insect cells |
Full length |
NM_002649 |
|
PI4K2A, Active |
P21-102G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_018425 |
|
PI4K2B, Active |
P22-102G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_018323 |
|
PI4KA, Active |
P31-102G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_002650 |
|
PI4KB, Active |
P32-102G |
Human |
GST tag |
Sf9 insect cells |
Full length |
BC000029 |
|
PIK3C2A, Active |
P23-112G |
Human |
GST tag |
Sf9 insect cells |
299-end |
NM_002645 |
|
PIK3C2B, Active |
P24-112BG |
Human |
GST tag |
Sf9 insect cells |
850-end |
BC144342 |
8、高活性甲基转移酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
COMT, Active |
C339-381G |
Human |
GST tag |
Sf9 insect cells |
27-271 |
NM_000754 |
|
DNMT3A, Active |
D353-380G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
BC043617 |
|
DNMT3B, Active |
D353-380BG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
BC111933 |
|
DNMT3L, Active |
D353-380CG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
BC002560 |
|
DOT1L (KMT4), Active |
D344-381G |
Human |
GST tag |
Sf9 insect cells |
1-435 |
NM_032482 |
|
EHMT1 (KMT1D), Active |
E317-381G |
Human |
GST tag |
Sf9 insect cells |
895-end |
NM_024757 |
|
EHMT2, Active |
E318-381G |
Human |
GST tag |
Sf9 insect cells |
807-end |
NM_006709 |
|
LCMT1, Active |
L321-380G |
Human |
GST tag |
Sf9 insect cells |
Full length |
NM_016309 |
|
MLL1 (KMT2A), Active |
M341-381G |
Human |
GST tag |
Sf9 insect cells |
3738-end |
NM_005933 |
|
MLL2 (KMT2D), Active |
M342-381G |
Human |
GST tag |
Sf9 insect cells |
5317-end |
NM_003482 |
|
MLL3 (KMT2C), Active |
M343-381G |
Human |
GST tag |
Sf9 insect cells |
4689-end |
NM_170606 |
9、高活性磷酸酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
CDC25A, Active |
C04-20G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_001789 |
|
CDC25B, Active |
C04-20BG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_021873 |
|
CDC25C, Active |
C04-20CG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
BC019089 |
|
DUSP22 (MKPX), Active |
D22-20G |
Human |
GST tag |
E.coli |
Full Length |
NM_020185 |
|
PP1A, Active |
P13-20G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_002708 |
|
PP1B, Active |
P14-20G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_002709 |
|
PP2A alpha/PPP2R1A Complex, Active |
P16-20BH |
Human |
His tags |
Sf9 insect cells |
Full length |
NM_002715 |
|
PP2Aalpha, Active |
P16-20G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_002715 |
10、高活性磷酸二酯酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
基因号 |
|
PDE10A, Active |
P98-31G |
Human |
GST tag |
Sf9 insect cells |
71-end |
NM_006661 |
|
PDE1A, Active |
P89-30H |
Human |
His tag |
Sf9 insect cells |
Full Length |
NM_005019 |
|
PDE1B, Active |
P89-30BG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_000924 |
|
PDE1C, Active |
P89-30CG |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_005020 |
|
PDE2A, Active |
P90-30G |
Human |
GST tag |
Sf9 insect cells |
Full Length |
NM_002599 |
|
PDE3A, Active |
P91-31G |
Human |
GST tag |
Sf9 insect cells |
669-end |
NM_000921 |
|
PDE3B, Active |
P91-31BG |
Human |
GST tag |
Sf9 insect cells |
654-end |
NM_000922 |
|
PDE4A, Active |
P92-31G |
Human |
GST tag |
Sf9 insect cells |
332-end |
NM_001111307 |
|
PDE4B, Active |
P92-31BG |
Human |
GST tag |
Sf9 insect cells |
305-end |
NM_002600 |
|
PDE4C, Active |
P92-31CG |
Human |
GST tag |
Sf9 insect cells |
287-end |
NM_000923 |
11、高活性蛋白酶
|
品名 |
货号 |
种属 |
标记类型 |
表达系统 |
氨基序列 |
|
CPB (carboxypeptidase B), Active |
C560-31N |
Rat |
tag-free |
Yeast cells |
109-end |
|
EK (enterokinase), Active |
E535-31H |
Swine |
His tag |
Yeast cells |
800-end |
|
Immobilized Lys-c, Agarose |
L585-31AN |
Bacteria |
tag-free |
E.coli |
206-473 aa |
|
Immobilized Lys-c, Silica |
L585-31SN |
Bacteria |
tag-free |
E.coli |
206-473 aa |
|
Immobilized Thrombin, Agarose |
T565-31AN |
Human |
Native |
|
|
|
Immobilized Trypsin, Agarose |
T575-31AN |
Swine |
tag-free |
Yeast cells |
10-end |
|
Immobilized Trypsin, Silica |
T575-31SN |
Swine |
tag-free |
Yeast cells |
10-end |
|
KEX2 Protease, Active |
K525-31N |
Yeast |
tag-free |
Yeast cells |
110-660 aa |
|
Lys-c (lysyl-endopeptidase), Active |
L585-31N |
Bacteria |
tag-free |
E.coli |
206-473 aa |
二、抗体产品系列
1、亚型特异性抗体
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-AKT3 |
A18-63R |
Rabbit |
WB |
|
Anti-AMPK alpha 1 |
P47-63R |
Rabbit |
WB |
|
Anti-CAMK1 |
C07-60M |
Mouse, IgG1, 5H8 |
WB |
|
Anti-CHK2 |
C48-60M |
Mouse, IgG1, 7F9 |
WB |
|
Anti-ERK1 |
M29-60M |
Mouse, IgG1, E32 |
WB, IP |
|
Anti-ERK1 |
M29-60BM |
Mouse, IgG1, E19 |
WB, IP |
|
Anti-GSK3 alpha |
G08-63R |
Rabbit |
WB |
|
Anti-GSK3 beta |
G09-60M |
Mouse, IgG1, 6C2 |
WB |
|
Anti-HSP90 beta |
H36-63R |
Rabbit |
WB |
2、偶联修饰的抗体
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-5-Methylated Cytosine (5-methyl cytosine) |
C92-67S |
Sheep, IgG |
WB, IP |
|
Anti-Acetylated Lysine |
L95-66R |
Rabbit |
WB, ELISA, PI, IHC, IF |
|
Anti-Acetylated Lysine, Biotin Conjugated |
L95-66BR |
Rabbit |
WB, ELISA, IF, IHC, IP |
|
Anti-Acetylated Lysine, FITC Conjugated |
L95-66CR |
Rabbit |
For direct immunofluorescence assay |
|
Anti-Acetylated Lysine, HRP Conjugated |
L95-66DR |
Rabbit |
WB, ELISA, IF, IHC, IP |
|
Anti-Methylated Arginine (NG, NG-Di-methyl) |
A96-67R |
Rabbit |
WB, ELISA, IF, IHC, IP |
|
Anti-Methylated Arginine (NG-Mono-methyl) |
A95-67R |
Rabbit |
WB, ELISA, IF, IHC, IP |
|
Anti-Methylated Lysine (Tri- epsilon-N-methyl) |
L95-67R |
Rabbit |
WB, ELISA, IF, IHC, IP |
3、磷酸化特异性抗体
该产品系列共包括82款磷酸化特异性抗体，下表仅列部分产品，
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-phospho-14-3-3 beta (Ser58) |
Y71-365R |
Rabbit, IgG |
WB, IHC |
|
Anti-phospho-4EBP1 (Thr45) |
E35-365R |
Rabbit, IgG |
WB, IHC |
|
Anti-phospho-AKT1/2/3 (Ser473) |
A16-65BR |
Rabbit, IgG |
WB, IHC |
|
Anti-phospho-AKT1/2/3 (Thr308) |
A16-65R |
Rabbit, IgG |
WB, IHC |
|
Anti-phospho-ASK1 (Ser966) |
M13-65R |
Rabbit, IgG |
IHC |
|
Anti-phospho-ATF2 (Ser112) |
A10-565R |
Rabbit, IgG |
IHC |
|
Anti-phospho-ATF2 (Ser490 Ser498) |
A10-565BR |
Rabbit, IgG |
WB, IHC |
|
Anti-phospho-BRCA1 (Ser1423) |
B87-365R |
Rabbit, IgG |
IHC |
|
Anti-phospho-c-KIT (Tyr721) |
K06-65R |
Rabbit, IgG |
WB |
|
Anti-phospho-c-KIT (Tyr936) |
K06-65BR |
Rabbit, IgG |
IHC |
4、Primary Antibodies
该产品系列共包括279款上等原初抗体，下表仅列部分产品
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-4EBP1 |
E35-563R |
Rabbit, IgG |
WB, ELISA, ICC |
|
Anti-ADD1 |
A38-63R |
Rabbit |
WB |
|
Anti-AFX |
A42-63R |
Rabbit |
WB |
|
Anti-AKT (pan) |
A16-63R |
Rabbit |
WB |
|
Anti-AKT (pan) |
A16-63BR |
Rabbit |
WB |
|
Anti-AKT1 |
A16-60M |
Mouse, Monoclonal, 9A4 |
WB |
|
Anti-AKT1 |
A16-63CR |
Rabbit, IgG |
WB, ELISA, IF, IHC |
|
Anti-AKT2/3 |
A17-63BR |
Rabbit |
WB |
|
Anti-ALK2 |
A06-63R |
Rabbit, IgG |
WB, ELISA |
|
Anti-ALK4 |
A07-63R |
Rabbit, IgG |
WB, ELISA |
5、二抗
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-Mouse HRP |
G32-62G |
Goat Polyclonal |
WB, ELISA |
|
Anti-Rabbit HRP |
G33-62G |
Goat Polyclonal |
WB, ELISA |
6、Tag标签抗体
|
品名 |
货号 |
宿主 |
应用 |
|
Anti-DYKDDDDK |
F51-61M |
Mouse, IgG2b, FG4R |
WB, ELISA, IP, IS |
|
Anti-DYKDDDDK |
F51-63R |
Rabbit |
WB |
|
Anti-GFP |
G46-60M |
Mouse, IgG1, GF28R |
WB |
|
Anti-GST |
G52-61M |
Mouse, IgG2a, G2R |
WB |
|
Anti-HA |
H98-61M |
Mouse, IgG3, C10 |
WB, ELISA, IP, IS |
|
Anti-HA |
H98-63R |
Rabbit Polyclonal |
WB, ELISA, IP, IS |
|
Anti-His |
H99-61M |
Mouse, IgG2b, EH158 |
WB, ELISA, IP, IS |
|
Anti-His |
H99-63R |
Rabbit |
WB, ELISA, IP, IS |
|
Anti-Myc |
M86-61M |
Mouse, IgG1, M19 |
WB, ELISA, IP, IS |
|
Anti-RFP |
R46-61M |
Mouse, IgG1, RF5R |
WB |
|
Anti-V5 |
V05-61M |
Mouse, IgG1, V4RR |
WB, ELISA, IP, IS |
三、生物制剂产品系列
1、表观遗传酶激活剂
|
品名 |
货号 |
CAS 注册号 |
分子式 |
纯度 |
|
BML-278 |
S35-904C |
N/F |
C24H25NO4 |
>98% (TLC) |
|
CTPB |
P07-903 |
586976-24-1 |
C31H43ClF3NO2 |
98% |
|
Resveratrol |
S35-904 |
501-36-0 |
C14H12O3 |
>98% |
|
SirtAct |
S35-904E |
839699-72-8 |
C20H25N5O2 |
98% (TLC) |
2、表观遗传酶抑制剂
该产品系列共包括33款表观遗传研究酶类的抑制剂，下表仅列部分产品
|
品名 |
货号 |
应用 |
|
2’-Deoxy-5-fluorocytidine |
D353-904D |
不可逆DNA甲基转移酶抑制剂 |
|
5-Azacytidine |
D353-904 |
DNA低甲基化试剂 |
|
AK-7 |
S36-904 |
SIRT2抑制剂 |
|
APICIDIN |
H83-904B |
HDAC抑制剂 |
|
BIX-01294 3HCl |
S344-903 |
Histone甲基转移酶抑制剂 |
|
BML-210 |
H83-904C |
HDAC抑制剂 |
|
C-646 |
K311-903 |
HAT抑制剂 |
|
Chaetocin |
K421-904C |
Ly甲基转移酶抑制剂 |
|
CPTH2 |
K311-903B |
HAT 抑制剂 |
3、激酶激活剂
|
品名 |
货号 |
CAS 注册号 |
分子式 |
纯度 |
|
8-pCPT-2-O-Me-cAMP-AM |
R46-905 |
1152197-23-3 |
C20H21ClN5O8PS |
>97% (HPLC) |
|
AICAR |
P47-900B |
2627-69-2 |
C9H14N4O5 |
>99% (TLC); NMR (Conforms) |
4、激酶抑制剂
该产品系列共包括80款常用激酶抑制剂，下表仅列部分产品
|
品名 |
货号 |
应用 |
|
6BIO |
G08-900 |
GSK3 inhibitor |
|
A83-01 |
A09-900 |
ALK inhibitor |
|
AAL-993 |
F11-900C |
VEGF inhibitor |
|
AG-1296 |
P12-900 |
PDGFR Inhibitor |
|
AG-1478 |
E10-900B |
EGFR inhibitor |
|
AG-1517 |
K11-900B |
Tyrosine kinase inhibitor |
5、磷酸酶抑制剂
|
品名 |
货号 |
CAS 注册号 |
分子式 |
纯度 |
|
Cantharidin |
P16-902C |
56-25-7 |
C10H12O4 |
>98% (HPLC) |
|
EX-527 |
S35-904F |
49843-98-3 |
C13H13ClN2O |
98% (TLC) |
|
NSC-663284 |
C04-902 |
383907-43-5 |
C15H16ClN3O3 |
>98% |
|
Okadaic acid, free acid |
P16-902 |
78111-17-8 |
C44H68O13 |
>98% (TLC) |
6、内参siRNA
|
品名 |
货号 |
|
beta-Actin Positive Control siRNA |
A03-911D |
|
Cy3 Labeled Negative Control siRNA |
S02-910N |
|
FAM Labeled Negative Control siRNA |
S03-910N |
|
GAPDH Positive Control siRNA |
G13-911B |
|
Unlabeled Negative Control siRNA |
S01-910N |
7、激酶研究常用siRNA
该产品系列共包括782款常用激酶的siRNA，下表仅列部分产品
|
品名 |
货号 |
|
14-3-3 alpha/beta siRNA Set I |
Y71-911 |
|
14-3-3 epsilon siRNA Set I |
Y75-911 |
|
14-3-3 sigma siRNA Set I |
Y86-911 |
|
14-3-3 theta siRNA Set I |
Y84-911 |
|
14-3-3 zeta siRNA Set I |
Y92-911 |
|
4EBP1 siRNA Set I |
E35-911 |
|
AATK siRNA Set I |
A02-911 |
|
ABL1 siRNA Set I |
A03-911 |
|
ABL2 siRNA Set I |
A04-911 |
|
ACK siRNA Set I |
A05-911 |
|
ACVR2A siRNA Seti |
A35-911 |
四、信号通路蛋白及酶
该产品系列包括目前常用的信号通路蛋白及相关酶类，品种多种多样，包括：乙酰/甲基转移酶系列、适配蛋白系列、凋亡通路系列、精氨酸脱亚氨酶系列、细胞周期蛋白系列、细胞应激及分子伴侣蛋白系列、去乙酰化/甲基化酶系列、二氢嘧啶酶系列、双加氧酶系列、果糖激酶系列、G-蛋白家族产品系列、激酶突变体产品系列、蛋白激酶产品系列、脂质氧化酶系列、微管/肌动蛋白相关蛋白产品系列、磷脂酶C家族产品系列、超氧化物歧化酶产品系列、Tau蛋白及其相关产品系列、转录因子产品系列、泛素蛋白产品系列以及无活性激酶产品系列。
五、信号通路相关检测试剂
该产品系列包括检测试剂、脂类酶底物、寡氨酸底物、肽底物、蛋白酶底物等产品系列。
六、胞外配体蛋白
该产品系列包括细胞趋化因子、细胞因子及生长因子（生长因子共134种，下表仅列部分）。
|
品名 |
货号 |
应用 |
|
IP-10 |
I838-40N |
Cell Assay |
|
RANTES (CCL5) |
R801-40N |
Cell Assay |
|
SDF-1 |
S821-40N |
Cell Assay |
|
IFN-gamma |
I837-40N |
|
|
TNF-alpha |
T860-40N |
|
|
TNF-beta |
T861-40BG |
|
|
TNFB |
T861-40N |
|
|
TRAIL |
T880-40N |
|
