CF-Blue - anti Mouse CD115 - CSF-1R
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90,00 € tax excl.
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200,00 € tax excl.
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Product Description
- CSF-1R
- Rat IgG2a
- Flow Cytometry
- CF-Blue
- 0.5 mg/ml
- Mouse CD115 Recombinant Protein
- Mouse
- The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
- RUO
- CD115, clone AFS98, is a mAb intended for RUO in the identification of cells that express CD115. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
- Liquid
- Store in the dark at 2-8 °C
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CD115 is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.
- CSF-1R, M-CSFR, c-fms
- 12978
- 145 kD
