产品详情
简单介绍：
CAS:851536-75-9Formula:C55H87NO14MW:986.3Appearance:WhitesolidPurity:>95%byHPLC
详情介绍：
*Please inquire the availability for this product. Umirolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group, providing one of most hydrophobic tacrolimus analogues. Umirolimus has been targeted for use in stents and medical devices to suppress localised immunoreaction. Like all tacrolimus analogues, umirolimus binds to receptor protein, FKBP12. The complex then binds to mTOR and prevents it from interacting with target proteins. Umirolimus is extensively cited in the literature with over 70 citations.
Additional Information
| Synonyms | Biolimus, Biolimus A9, TRM 986 |
|---|---|
| Product # | U-2581 |
| CAS # | 851536-75-9 |
| Chemical Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,35R)-12-((2R)-1-[(1S,3R,4R)-4-(2-ETHOXYETHOXY)-3-METHOXYCYCLOHEXYL]-2-PROPANYL)-1,18-DIHYDROXY-19,30-DIMETHOXY-15,17,21,23,29,35-HEXAMETHYL-11,36-DIO XA-4-AZATRICYCLO[30.3.1.04,9]HEXATRIACONTA-16,24,26,28 |
| Formula | C55H87NO14 |
| MW | 986.3 |
| Appearance | White solid |
| Purity | >95% by HPLC |
| Storage Temp | -20 |
| Therapeutic Area | Oncological Disorders |
| Use | Use of umirolimus for treating cancer |
Additional Information
| MDL Number | MFCD22124433 |
|---|---|
| InChI | InChI=1S/C55H87NO14/c1-12-67-26-27-68-45-24-22-41(31-48(45)65-10)30-37(5)47-33-44(57)36(4)29-39(7)50(59)51(66-11)49(58)38(6)28-34(2)18-14-13-15-19-35(3)46(64-9)32-42-23-21-40(8)55(63,70-42)52(60)53(61)56-25-17-16-20-43(56)54(62)69-47/h13-15,18-19,29,34,36-38,40-43,45-48,50-51,59,63H,12,16-17,20-28,30-33H2,1-11H3/b15-13+,18-14+,35-19+,39-29+/t34-,36-,37-,38-,40-,41+,42+,43+,45-,46+,47+,48-,50-,51+,55-/m1/s1 |
| SMILES | CCOCCO[C@@H]1CC[C@H](C[C@H]1OC)C[C@@H](C)[C@@H]2CC(=O)[C@@H](/C=C(/[C@H]([C@H](C(=O)[C@@H](C[C@@H](/C=C/C=C/C=C(/[C@H](CC3CC[C@H]([C@@](O3)(C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)O)C)OC)\C)C)C)OC)O)\C)C |
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