产品详情
简单介绍：
CAS:1648707-58-7Formula:C14H21BrN2O.HClMW:349.7Appearance:whitepowderPurity:>98%
详情介绍：
The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a micro M ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain1.
References:
1. MT Perfetti et al. ACS Chem. Biol. 2015 10:1072
Additional Information
| Synonyms | 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride |
|---|---|
| Product # | M-2753 |
| CAS # | 1648707-58-7 |
| Formula | C14H21BrN2O . HCl |
| MW | 349.7 |
| Appearance | white powder |
| Purity | >98% |
| Solubility | May be dissolved in DMSO or water |
| Melting Point | 162-164°C |
| Storage Temp | -20°C |
Additional Information
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