产品详情
简单介绍：
CAS:314245-33-5Formula:C18H21FN2OMW:300.37Appearance:Whitetooff-whiteSolidPurity:98%byHPLC
详情介绍：
A cell-permeable, reversible and selective inhibitor of the deubiquitinating activity of human USP14 (IC= 4-5 M). IU1 promotes cell survival during proteotoxic stress and selectively stimulates ubiquitin-dependent protein degradation in vitro at 34M.
Additional Information
| Synonyms | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone |
|---|---|
| Product # | U-2474 |
| CAS # | 314245-33-5 |
| Chemical Name | 1-[1-(4-fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)-ethanone |
| Formula | C18H21FN2O |
| MW | 300.37 |
| Appearance | White to off-white Solid |
| Purity | 98% by HPLC |
| Solubility | DMSO (~20 mg/ml) |
| Storage Temp | -20°C |
| Use | IU1 is an inhibitor of USP14, a deubiquitinating enzyme associated with the proteasome |
Additional Information
| MDL Number | MFCD01917473 |
|---|---|
| ChemACX | X2815842-9 |
| InChI | InChI=1S/C18H21FN2O/c1-13-11-17(18(22)12-20-9-3-4-10-20)14(2)21(13)16-7-5-15(19)6-8-16/h5-8,11H,3-4,9-10,12H2,1-2H3 |
| SMILES | Cc1cc(c(n1c2ccc(cc2)F)C)C(=O)CN3CCCC3 |
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