产品详情
简单介绍：
CAS:443913-73-3Formula:C22H24BrFN4O2MW:475.35Appearance:WhiteSolidPurity:98%byHPLC
详情介绍：
A potent inhibitor of kinase insert domain-containing receptor tyrosine kinase activity (IC= 40 nM). This compound also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC= 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC= 500 nM) but shows selectivity relating to a range of other tyrosine and serine-threonine kinases.
Additional Information
| Synonyms | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima |
|---|---|
| Product # | V-2475 |
| CAS # | 443913-73-3 |
| Chemical Name | N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; ZD6474, Zactima |
| Formula | C22H24BrFN4O2 |
| MW | 475.35 |
| Appearance | White Solid |
| Purity | 98% by HPLC |
| Solubility | DMSO (30 mg/ml) or EtOH (10 mg/ml) |
| Storage Temp | -20°C |
| Therapeutic Area | Oncological Disorders |
| Use | Vandetanib is an antagonist of VEGFR (Flk and Flk) and EGFR families |
Additional Information
| MDL Number | MFCD07772346 |
|---|---|
| ChemACX | X1614613-9 |
| InChI | InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) |
| SMILES | CN1CCC(CC1)COc2cc3c(cc2OC)c(ncn3)Nc4ccc(cc4F)Br |
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