Vildagliptin increases β cell mass by not only directly affecting cell kinetics but also by indirectly reducing cell apoptosis, oxidative stress and endoplasmic reticulum stress in diabetic mice.
产品详情
简单介绍：
CAS:274901-16-5Formula:C17H25N3O2MW:303.4Appearance:WhitePowder
详情介绍：
A potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1)1. Delaying the degradation of GLP-1 extends the action of insulin and suppresses the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia)2. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model3. Displays protective effects on b-cells by inhibition of ER stress in a mouse model4. Clinically useful antidiabetic agent.
Additional Information
| Synonyms | (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile; LAF237; 2-Pyrrolidinecarbonitrile |
|---|---|
| Product # | V-2421 |
| CAS # | 274901-16-5 |
| Chemical Name | (S)-1-[N-(3-hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile |
| Formula | C17H25N3O2 |
| MW | 303.4 |
| Appearance | White Powder |
| Solubility | May be dissolved in DMSO (45 mg/ml); or DMF (20 mg/ml); or ethanol (20 mg/ml) |
| Storage Temp | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
| Use | Laboratory chemicals, manufacture of substances. |
Additional Information
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