产品详情
简单介绍：
CAS:479543-46-9Formula:C19H12F4N4O2MW:404.32Appearance:WhitesoildPurity:99%byHPLC
详情介绍：
A p38 MAP kinase inhibitor. VX-702 dose-dependently inhibited the production of IL-6, IL-1 and TNF (IC= 59, 122 and 99 ng/ml, respectively). Pre-incubation of platelets with VX-702 (1 M) completely or partially inhibited platelet agonist induced p38 activation (IC= 4 to 20 nM).
Additional Information
| Synonyms | 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide |
|---|---|
| Product # | V-2481 |
| CAS # | 479543-46-9 |
| Chemical Name | 2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide |
| Formula | C19H12F4N4O2 |
| MW | 404.32 |
| Appearance | White soild |
| Purity | 99% by HPLC |
| Solubility | DMSO |
| Storage Temp | -20°C |
| Therapeutic Area | Inflammatory Diseases |
| Use | VX-702, a novel p38 MAPK inhibitor, in rheumatoid arthritis |
Additional Information
| MDL Number | MFCD11616590 |
|---|---|
| ChemACX | X1829255-4 |
| InChI | InChI=1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29) |
| SMILES | C1=CC(=C(C(=C1)F)N(C2=NC(=C(C=C2)C(=O)N)C3=C(C=C(C=C3)F)F)C(=O)N)F |
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