产品详情
简单介绍：
CAS:19545-26-7Formula:C23H24O8MW:428.4Appearance:Off-WhitetoPaleYellowSolidPurity:98%
详情介绍：
A fungal metabolite that specifically inhibits phosphatidylinositol 3-kinase (PI-3), mitogen-activated protein kinase(MAPK) and myosin light-chain kinase (MLCK).Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis, Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.Nongenotropic, Anti-Apoptotic Signaling of 1,25(OH)2-Vitamin D3 and Analogs through the Ligand Binding Domain of the Vitamin D Receptor in Osteoblasts and Osteocytes: MEDIATION BY Src, PHOSPHATIDYLINOSITOL 3-, AND JNK KINASES
Additional Information
| Synonyms | Wortmannin, Penicillium wortmanni, KY12420, Antibiotic SL-2052 |
|---|---|
| Product # | W-1022 |
| CAS # | 19545-26-7 |
| Chemical Name | (1alpha,11alpha)-11-(Acetyloxy)-1- (methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4- bc)furan-3,7,17-trione |
| Formula | C23H24O8 |
| MW | 428.4 |
| Appearance | Off-White to Pale Yellow Solid |
| Purity | 98% |
| Solubility | Soluble in Methanol and DMSO |
| Melting Point | 240°C |
| Storage Temp | -20°C |
| Therapeutic Area | Infectious Diseases |
| Use | Wortmannin, a fungal metabolite, is a potent and selective inhibitor of PI 3-kinase |
Additional Information
| Merck Index | Merck Index: 13.10110.2001 |
|---|---|
| MDL Number | MFCD00133927 |
| ChemACX | X1097086-6 |
| InChI | InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1 |
| SMILES | CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@@]4(c5c(coc5C3=O)C(=O)O[C@@H]4COC)C)C |
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