产品详情
简单介绍：
CAS:284028-89-3Formula:C14H11F3N2OSMW:312.31Appearance:WhiteSolidPurity:98%byHPLC
详情介绍：
A Tankyrase (TNKS) inhibitor (IC= 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation ofcatenin degradation and stabilization of axin. Inhibits proliferation of the-catenin-dependent colon carcinoma cell line DLD-1.
Additional Information
| Synonyms | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one |
|---|---|
| Product # | X-2484 |
| CAS # | 284028-89-3 |
| Chemical Name | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one |
| Formula | C14H11F3N2OS |
| MW | 312.31 |
| Appearance | White Solid |
| Purity | 98% by HPLC |
| Solubility | DMSO (50 mM) |
| Melting Point | 207.14 °C |
| Storage Temp | -20°C |
| Therapeutic Area | Oncological Disorders |
| Use | A potent inhibitor of beta-catenin, TNKS1, and TNKS2.XAV939 inhibits colony formation of APC-deficient colorectal cancer cells |
Additional Information
| MDL Number | MFCD16879017 |
|---|---|
| ChemACX | X1833197-6 |
| InChI | InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20) |
| SMILES | c1cc(ccc1c2[nH]c(=O)c3c(n2)CCSC3)C(F)(F)F |
相关文章
