产品详情
简单介绍：
Anti-CYP17A1 Antibody
详情介绍：
Overview
| Name: | Anti-CYP17A1 Antibody See all CYP17A1 primary antibodies
|
| Description: | Goat polyclonal antibody to CYP17A1. |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human |
| Immunogen: | Synthetic peptide corresponding to Human CYP17A1 (internal region). |
| Sequence: | C-LFKDGDQKLEK |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 μg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty. |
| Involvement in Disease: | Adrenal hyperplasia 5: A form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short ***** stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic). |
| Sequence Similarities: | Belongs to the cytochrome P450 family. |
| Post-Translational Modification: | Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity. |
| Cellular Location: | Membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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