产品详情
简单介绍：
Anti-FOXL2 Antibody
详情介绍：
Overview
| Name: | Anti-FOXL2 Antibody See all FOXL2 primary antibodies
|
| Description: | Goat polyclonal antibody to FOXL2. |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide corresponding to Human FOXL2 (C terminal). |
| Sequence: | C-DSKTGALHSRLDL |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 μg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional repressor of STAR. Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element. |
| Tissue Specificity: | Expressed in the mesenchyme of developing eyelids. Expressed in ovaries throughout development and *****hood, localized to the undifferentiated granulosa cells in small and medium follicles as well as cumulus cells of preovulatory follicles. Expressed in the pituitary. |
| Post-Translational Modification: | Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity. |
| Cellular Location: | Nucleus. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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