产品详情
简单介绍：
Anti-CD11b Antibody
详情介绍：
Overview
| Name: | Anti-CD11b Antibody See all CD11b primary antibodies
|
| Description: | Rat monoclonal (M1/70) antibody to CD11b. |
| Specificity: | The rat monoclonal antibody M1/70 detects CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions. |
| Applications: | FC, IP, IHC-Fr, FUNC |
| Reactivity: | Human, Non-Human Primates, Mouse, Rabbit |
| Immunogen: | B10 mouse spleen cells enriched for T cells. |
| Host: | Rat |
| Clonality: | Monoclonal |
| Clone: | M1/70 |
| Isotype: | IgG2b |
| Conjugate: | Unconjugated |
| Purification: | Protein G chromatography. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, without Azide (0.2 μm filter sterilised). Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:8986723, PubMed:9382884, PubMed:9862668). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (By similarity). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (PubMed:8986723). May play a role in mast cell development (PubMed:9862668). |
| Tissue Specificity: | Predominantly expressed in monocytes and granulocytes (PubMed:3887182, PubMed:8986723). Expressed in a subset of peritoneal mast cells (PubMed:9862668). |
| Sequence Similarities: | Belongs to the integrin alpha chain family. |
| Cellular Location: | Cell membrane. Membrane raft. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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