产品详情
简单介绍：
Anti-MMP2 Antibody
详情介绍：
Overview
| Name: | Anti-MMP2 Antibody See all MMP2 primary antibodies
|
| Description: | Rabbit polyclonal antibody to MMP2. |
| Applications: | WB, ICC/IF, IHC |
| Dilutions: | WB: 1:10,000. IF/ICC and IHC: 1:500-1:1,000. |
| Reactivity: | Human, Horse, Cow, Porcine, Chicken, Rat, Mouse |
| Immunogen: | Human C-terminal peptide (aa. 475-490). |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Immunogen affinity purified. |
| Concentration: | 1 mg/ml |
| Product Form: | Liquid |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues (By similarity). |
| Sequence Similarities: | Belongs to the peptidase M10A family. |
| Post-Translational Modification: | Phosphorylation on multiple sites modulates enzymatic activity. Phosphorylated by PKC in vitro (By similarity). |
| Cellular Location: | Secreted > Extracellular space > Extracellular matrix. Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes (By similarity). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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