产品详情
简单介绍：
Anti-CD54 Antibody
详情介绍：
Overview
| Name: | Anti-CD54 Antibody See all ICAM1 primary antibodies
|
| Description: | Mouse monoclonal (MEM-111) antibody to CD54. |
| Specificity: | The antibody MEM-111 reacts with CD54 (ICAM-1), a 85-110 kDa type I transmembrane glycoprotein (receptor for rhinovirus). The expression of CD54 is upregulated by activation; it is expressed on activated endothelial cells, T lymphocytes, B lymphocytes, monocytes, macrophages, granulocytes and dendritic cells. |
| Applications: | FC, WB, IHC-P, ELISA |
| Reactivity: | Rat, Human, Bovine |
| Immunogen: | Raji human Burkitt's lymphoma cell line. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Clone: | MEM-111 |
| Isotype: | IgG2a |
| Conjugate: | Unconjugated |
| Purification: | Protein A chromatography. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity). |
| Sequence Similarities: | Belongs to the immunoglobulin superfamily. ICAM family. |
| Post-Translational Modification: | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Cellular Location: | Membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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