产品详情
简单介绍：
Anti-CD59 Antibody
详情介绍：
Overview
| Name: | Anti-CD59 Antibody See all CD59 primary antibodies
|
| Description: | Mouse monoclonal (MEM-43) antibody to CD59. |
| Specificity: | The antibody MEM-43 reacts with well defined epitope (W40, R-53) on CD59 (Protectin), an 18-20 kDa glycosylphosphatidylinositol (GPI)-anchored glycoprotein expressed on all hematopoietic cells; it is widely present on cells in all tissues. |
| Applications: | FC, IP, IHC-P |
| Reactivity: | Human |
| Immunogen: | Thymocytes and T lymphocytes. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Clone: | MEM-43 |
| Isotype: | IgG2a |
| Conjugate: | Unconjugated |
| Purification: | Protein A chromatography. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
| Involvement in Disease: | Hemolytic anemia, CD59-mediated, with or without polyneuropathy: An autosomal recessive disorder characterized by infantile onset of chronic hemolysis and a relapsing-remitting polyneuropathy, often exacerbated by infection, and manifested as hypotonia, limb muscle weakness, and hyporeflexia. |
| Post-Translational Modification: | N- and O-glycosylated. The N-glycosylation mainly consists of a family of biantennary complex-type structures with and without lactosamine extensions and outer arm fucose residues. Also significant amounts of triantennary complexes (22%). Variable sialylation also present in the Asn-43 oligosaccharide. The predominant O-glycans are mono-sialylated forms of the disaccharide, Gal-beta-1,3GalNAc, and their sites of attachment are probably on Thr-76 and Thr-77. The GPI-anchor of soluble urinary CD59 has no inositol-associated phospholipid, but is composed of seven different GPI-anchor variants of one or more monosaccharide units. Major variants contain sialic acid, mannose and glucosamine. Sialic acid linked to an N-acetylhexosamine-galactose arm is present in two variants. |
| Cellular Location: | Cell membrane. Secreted. Soluble form found in a number of tissues. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
