产品详情
简单介绍：
Anti-CD8a Antibody
详情介绍：
Overview
| Name: | Anti-CD8a Antibody See all CD8 alpha primary antibodies
|
| Description: | Rat monoclonal (53-6.7) antibody to CD8a. |
| Specificity: | The rat monoclonal antibody 53-6.7 recognizes mouse CD8a (32-34 kDa; alpha chain of the CD8 antigen). |
| Applications: | FC, IP, IHC-P, IHC-Fr, ICC, FUNC |
| Reactivity: | Mouse |
| Immunogen: | Mouse spleen cells. |
| Host: | Rat |
| Clonality: | Monoclonal |
| Clone: | 53-6.7 |
| Isotype: | IgG2a |
| Conjugate: | Unconjugated |
| Purification: | Protein A chromatography. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. |
| Post-Translational Modification: | Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts. |
| Cellular Location: | Cell membrane. Cd8a localizes to lipid rafts only when associated with its partner Cd8b. |
| Database Links: |
|
| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
相关文章
