产品详情
简单介绍：
Anti-ELAVL1 Antibody
详情介绍：
Overview
| Name: | Anti-ELAVL1 Antibody See all ELAVL1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to ELAVL1. |
| Applications: | WB, IHC, IF |
| Dilutions: | WB: 1:500 - 1:2000, IHC: 1:100 - 1:200, IF: 1:50 - 1:200. |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant protein of human ELAVL1. |
| Protein Length: | 326 |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Affinity purification. |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). |
| Tissue Specificity: | Ubiquitous. Detected in brain, liver, thymus and muscle. |
| Sequence Similarities: | Belongs to the RRM elav family. |
| Post-Translational Modification: | Phosphorylated by MAPKAPK2 (PubMed:14517288). Phosphorylated by PRKCD (PubMed:18285462). |
| Cellular Location: | Cytoplasm. Nucleus. Translocates into the cytoplasm following phosphorylation by MAPKAPK2 (PubMed:14517288). Likewise, phosphorylation by PRKCD promotes translocation from the nucleus into the cytoplasm, where it is associated with free and cytoskeleton-bound polysomes (PubMed:18285462). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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