产品详情
简单介绍：
Anti-alpha Fetoprotein Antibody
详情介绍：
Overview
| Name: | Anti-alpha Fetoprotein Antibody See all alpha Fetoprotein primary antibodies
|
| Description: | Mouse monoclonal (AFP-01) antibody to alpha Fetoprotein. |
| Specificity: | The antibody AFP-01 reacts with human alpha-Fetoprotein (AFP), a 70 kDa oncofetal antigen. AFP is a major fetal plasma protein, but is not present in healthy ***** tissues. Elevated AFP concentrations in ***** plasma may be an early marker of hepatocellular carcinoma or teratoblastoma, while high concentrations in amniotic fluid may indicate severe congenital defects of a fetus. |
| Applications: | IP, ELISA, WB |
| Reactivity: | Human |
| Immunogen: | Purified alpha Fetoprotein. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Clone: | AFP-01 |
| Isotype: | IgG1 |
| Conjugate: | Unconjugated |
| Purification: | Purified from ascites by precipitation methods. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. |
| Tissue Specificity: | Plasma. Synthesized by the fetal liver and yolk sac. |
| Involvement in Disease: | Alpha-fetoprotein deficiency: A benign condition characterized by undetectable AFP levels in the amniotic fluid. Affected individuals are asymptomatic and present normal development. Alpha-fetoprotein, hereditary persistence: A benign autosomal dominant condition characterized by continued expression of alpha-fetoprotein in ***** life. |
| Sequence Similarities: | Belongs to the ALB/AFP/VDB family. |
| Post-Translational Modification: | Independent studies suggest heterogeneity of the N-terminal sequence of the mature protein and of the cleavage site of the signal sequence. |
| Cellular Location: | Secreted. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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