产品详情
简单介绍：
Anti-CD71 Antibody
详情介绍：
Overview
| Name: | Anti-CD71 Antibody See all CD71 primary antibodies
|
| Description: | Mouse monoclonal (MEM-189) antibody to CD71. |
| Specificity: | The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. |
| Applications: | WB, FC, IP |
| Reactivity: | Human |
| Immunogen: | KG1 human acute myelogenous leukaemia cell line. |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Clone: | MEM-189 |
| Isotype: | IgG1 |
| Conjugate: | Unconjugated |
| Purification: | Protein A chromatography. |
| Concentration: | 1 mg/ml |
| Purity: | > 95% (by SDS-PAGE) |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 8.0, with 15mM Sodium Azide. |
| Storage: | Store at 2-8°C. |
Target
| Function: | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). |
| Involvement in Disease: | Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia. |
| Sequence Similarities: | Belongs to the peptidase M28 family. M28B subfamily. |
| Post-Translational Modification: | N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated. |
| Cellular Location: | Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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