产品详情
简单介绍：
Anti-HO-1 Antibody
详情介绍：
Overview
| Name: | Anti-HO-1 Antibody See all HO-1 primary antibodies
|
| Description: | Rabbit polyclonal antibody to HO-1 |
| Specificity: | HO-1 pAb detects endogenous levels of HO-1 protein. |
| Applications: | WB, IHC, ICC, IP |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant full length Human HO-1. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 34 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol. |
Target
| Function: | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis. |
| Tissue Specificity: | Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level). |
| Involvement in Disease: | Heme oxygenase 1 deficiency: A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. |
| Sequence Similarities: | Belongs to the heme oxygenase family. |
| Cellular Location: | Microsome. Endoplasmic reticulum membrane. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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