产品详情
简单介绍：
Anti-Actived-Caspase-9 p35 (D315) Antibody
详情介绍：
Overview
| Name: | Anti-Actived-Caspase-9 p35 (D315) Antibody See all Actived-Caspase-9 p35 primary antibodies
|
| Description: | Rabbit polyclonal antibody to Actived-Caspase-9 p35 (D315) |
| Specificity: | Actived-Caspase-9 p35 (D315) pAb detects detects endogenous levels of the 35 kDa large fragment of caspase-9 following cleavage at aspartic acid 315. |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide, corresponding to amino acids 300-350 of Human Caspase 9. |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Conjugate: | Unconjugated |
| Molecular Weight: | ~ 35 kDa |
| Purity: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE). |
| Product Form: | 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2. |
Target
| Function: | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). |
| Tissue Specificity: | Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. |
| Sequence Similarities: | Belongs to the peptidase C14A family. |
| Post-Translational Modification: | Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events. |
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