产品详情
简单介绍：
Anti-AIF1 Antibody
详情介绍：
Overview
| Name: | Anti-AIF1 Antibody See all AIF1 primary antibodies
|
| Description: | Goat polyclonal antibody to AIF1. |
| Applications: | ELISA, WB, IHC |
| Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide corresponding to Human AIF1 (internal region). |
| Sequence: | C-NKQFLDDPKYSSDED |
| Host: | Goat |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Unconjugated |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 100 μg at 0.5 mg/ml. |
| Product Form: | Liquid |
| Formulation: | Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA. |
| Storage: | Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. |
Target
| Function: | Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. |
| Tissue Specificity: | Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages. |
| Post-Translational Modification: | Phosphorylated on serine residues. |
| Cellular Location: | Cytoplasm > Cytoskeleton. Cell projection > Ruffle membrane. Cell projection > Phagocytic cup. Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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