产品详情
简单介绍：
Anti-GDF15 Antibody
详情介绍：
Target
| Function: | Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture and chromosome segregation (By similarity). Necessary for sumoylation of FOXL2 and KAT5. Sumoylates p53/TP53 at 'Lys-386' (By similarity). |
| Tissue Specificity: | Broadly expressed, with highest levels in spleen and lung (at protein level). |
| Sequence Similarities: | Belongs to the ubiquitin-conjugating enzyme family. |
| Post-Translational Modification: | Phosphorylation at Ser-71 significantly enhances SUMOylation activity. |
| Cellular Location: | Nucleus. Cytoplasm. Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). |
| Database Links: |
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| Synonyms: | |
| Information: | Target information shown above is from the UniProt Consortium. |
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